Baki ERDEMa, Osman AŞICIOĞLUa, İlkbal TEMEL YÜKSELa, Berna ASLAN ÇETİNa, Nur Betül ARSLANa, Suat Can ULUKENTb, İpek Yıldız ÖZAYDINc, Özgür AKBAYIRa Departments of aGynecologic Oncology, bGeneral Surgery, cPathology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, TURKEY
DOI: 10.5336/jcog.2018-64214 Article Language: EN 348 Viewed -- 187 Downloaded
ABSTRACT Objective: The objectives of this study were to conduct a retrospective review of patients with adult granulosa cell tumors (AGCTs) to validate the effect of full surgical staging and adjuvant chemotherapy, and to identify the factors influencing disease-free survival (DFS) and overall survival (OS). Material and Methods: The database and patient files available at our gynecological oncology department were searched to identify women who had undergone primary surgery for an ovarian tumor and whose final diagnosis was stage I/II AGCT. A total of 41 patients with earlystage AGCT were included in the analysis. Results: The majority of the cases were Stage I AGCT (63.4%). The median OS of the patients was 54.3 months. Full stage surgery, age, and lymphadenectomy were not independent risk factors for the involvement of lymph nodes in AGCTs. For patients with full surgical staging, pelvic and para-aortic lymphadenectomy were not independent prognostic factors for DFS and OS. Conclusion: Initial stage, age, lymphadenectomy, and full stage surgery did not influence DFS, OS, or recurrence of AGCTs. Furthermore, age, bilaterality, and preoperative ultrasound image did not influence the involvement of lymph nodes in AGCTs.
Keywords: Adult granulosa cell tumor; lymphadenectomy; early stage; recurrence