Mehmet BÜLBÜL,a Berna DİLBAZ,b Bilge AYDIN TÜRK,c Filiz HATİPOĞLU,a Esra BOYARd aDepartment of Obstetrics and Gynecology, Adıyaman University Faculty of Medicine, Adıyaman, Turkiye bDepartment of Obstetrics and Gynecology, Health Sciences University Etlik Zübeyde Hanım Health Practice and Research Hospital, Ankara, Turkiye cDepartment of Pathology, Adıyaman University Faculty of Medicine, Adıyaman, Turkiye dClinic of Obstetrics and Gynecology, Adıyaman University Training and Research Hospital, Adıyaman, Turkiye
DOI: 10.5336/jcog.2018-62794 Article Language: EN 232 Viewed -- 180 Downloaded
ABSTRACT Objective: The aim of this study is to identify the prevalence of oncogenic human papillomavirus (HPV) genotypes in women with abnormal smear or cervical HPV infection and histopathological examination of colposcopy-guided biopsies in women with HPV positivity in a southeastern city of Turkey. Material and Methods: One-hundred eighty-nine women who were referred for either HPV positivity or an abnormal smear result were recruited to the study. The prevalence of oncogenic and non-oncogenic HPV genotypes was analyzed according to the histopathological diagnosis of the specimens obtained via cervical smear and colposcopy-guided biopsies. Results: Out of 189 patients, 36 (19,0%) had an abnormal smear result and 153 (81,0%) had a positive HPV test. Out of 153 patients, 33,9% (n=64) were positive for HPV 16 and/or 18 and 47.1 (n=89) were positive for other HPV genotypes. While 112 patients had positivity for one HPV genotype 21.7% were positive for 2 or more HPV genotypes. The most frequent HPV genotypes were HPV 16 (24.2%), HPV 18 (8.2%), HPV 51 (7.8%), HPV 39 (5.9%) and HPV 53 (4.6%). The highest prevalence of HPV16-18 was in the 30-49 age group. HPV 16 and 18 positivity were recorded in 20.2% of the cases with benign pathology while the prevalence was 34.7% in CIN I, 57.1% in CIN II-III and 100% in cases with invasive cervical carcinoma. Conclusion: HPV 16 and 18 were the most prevalant oncogenic HPV genotypes in the studied patient group and their presence was related with the severity of the cervical pathology.
Keywords: Cervical intraepithelial neoplasia; colposcopy; human papilloma virus