E-ISSN: 2619-9467

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Year 2007 - Volume 17 - Issue 4

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Polycystic Ovary Syndrome and Ovulation Induction
Polikistik Over Sendromu Ve Ovulasyon İndüksiyonu

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Turkiye Klinikleri J Gynecol Obst. 2007;17(4):298-309

Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
In polycystic ovary syndrome (PCOS), the first treatment choice is clomiphene citrate. A significant proportion (?î20%) of women remain anovulatory following this drug. Induction of ovulation exogenous gonadotrophins is generally indicated in this patients. Low-dose proto-cols of FSH are the second line of treatment, effective in inducing monofollicular development. This treatment modality has been proven to be effective, but treatment requires skill and experience to avoid multiple pregnancies and ovarian hyperstimulation syndrome. Laparo-scopic ovarian drilling (LOD) can be an alternative but not as a first choice treatment in clomiphene-resistant patients. In obese women with PCOS, weight loss and exercise should be recommended as the first line of therapy. Newer agents including aromatase inhibitors and insulin sensitizers, although promising, need further evaluation.
ÖZET
Polikistik over sendromunda (PKOS) ovulasyon indüksiyonu uygulamalarında ilk seçenek klomifen sitratdır. Ancak olguların %20'si klomifene rezistans göstermektedir. Klomifene rezistant olgularda ikinci seçenek gonadotropinler ile indüksiyonudur. En çok kabul gören yöntem kronik low-dose protokoldür. Laparoskopik ovaryan drilling (LOD), klomifen resistant seçilmiş olgularda uygula-nabilir. Obez olgularda kilo verilmesi, egzersiz uygulamalarının dışında insulin duyarlaştırıcı ajanlarda sıklıkla kullanılmaktadır. Aromataz inhibitörleri ile ilgili daha kapsamlı çalışmalara ihtiyaç vardır.