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Year 1993 - Volume 3 - Issue 4

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The Prognostic Predictive Valve Of Maternal Serum Ca-125 Levels In Abortus Imminens Cases
Abortus İmminens Olgularında Maternal Serum CA-125 Ölçümünün Prognostik Değeri

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Turkiye Klinikleri J Gynecol Obst. 1993;3(4):293-6

Article Language: TR
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ÖZET
37 abortus imminens olgusunda maternal serum CA-125 seviyesinin gebelik prognozunu belirleyicilik değeri araştırılmıştır. Vaginal kanamalı habituel abortus anamnezi vermeyen ultrasonografik olarak tek gebelik saptanan 7-12 gebelik haftasında ve son adet tarihi ile uyum gösteren 37 abortus imminens olgusu çalışma grubunu, 20 sorunsuz gebe de kontrol grubunu oluşturdu. Çalışma grubunda abortusla sonlananların ortalama serum CA-125 değerinin, abortusla sonlanmayan ve gebeliği devam edenlere göre anlamlı düzeyde yüksek olduğu belirlendi (p< 0.01). Çalışma grubunda CA-125> 60 U/ml sınır alındığında pozitif belirleyicilik değeri %73, spesifite değeri %87, CA-125> 80 U/ml sınır alındığında pozitif belirleyicilik değeri %100, spesifite değeri %200 olarak tesbit edilmiştir. Çalışma grubunda abortusla sonlananlarla sorunsuz gebe olarak taburcu edilenler arasında vaginal kanama süresi açısından anlamlı fark bulundu (p< 0.01). Bu veriler abortus imminens olgularında prognozu belirlemede maternal serum CA-125 ölçümünün kullanılabileceğini düşündürmektedir.
ABSTRACT
The prognostic predictive value of maternal serum CA-125 levels was investigated in 37 cases of threatened abortion. 37 cases of threatened abortion who had vaginal bleeding, didn't have history of recurrent pregnancy loss, having ultrasonographically verified viable single fetus with gestational ages ranging from 7 to 12 weeks correlated with last menstrual dating constituted the study group, 20 healty pregnants constituted the control group. The mean serum CA-125 value of the patients whose pregnancy outcome was unfavourable was significantly higher than that of the patients wih favourable outcome (p< 0.01). In the study group when the cut of level of maternal serum CA-125 was selected as > 60 U/ml, positive predictive value was found to be 73%, specifity was 87% for spontaneous abortion when the cut of maternal serum CA-125 was selected as >80 U/ml the specifity increased to 100% and positive predictive value also increased to the rate of 100% for spontaneous abortion positive correlation was established between mean maternal serum CA-125 level and duration of vaginal bleeding. In the study group, duration of vaginal bleeding was significantly different between the aborters and patients with favourable outcome (p> 0.01). These findings suggested that maternal serum CA-125 measurement in threatened abortion can be used to determine the outcome of pregnancy.