E-ISSN: 2619-9467

Contents    Publication Date: 22 Jun 2022
Year 2022 - Volume 32 - Issue 2

Open Access

Peer Reviewed

SCIENTIFIC LETTER
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Anti-Thyroid Peroxidase Antibody and Hypothyroidism in Recurrent Pregnancy Miscarriage

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JCOG. 2022;32(2):67-71
DOI: 10.5336/jcog.2021-86703
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Thyroid disorders are one of the endocrine diseases that may develop during pregnancy. Thyroid autoimmunity (TAI) is commonly prevalent among these diseases in women of childbearing age. TAI includes thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies, and thyrotropin receptor antibodies. However, TPOAb is the most common antithyroid autoantibodies observed in women with recurrent miscarriage (RM) history. Although the precise mechanisms of the TPOAb's role in RM are not fully understood, multiple studies have found that the presence of TPOAb at a high level may increase the risk of recurrent pregnancy loss. The literature in this article was conducted based on published databases in PubMed, Web of Science, Google Scholar, and some international organizations It aims to emphasize the importance of screening for TPOAb in women with RM. It concludes that, according to published studies, the TPOAb could be considered as a good indicator of women at risk of RM.
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