E-ISSN: 2619-9467

Contents    Cover    Publication Date: 06 Jun 2023
Year 2023 - Volume 33 - Issue 2

Open Access

Peer Reviewed

CASE REPORTS
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Pregnancy in Parkinson's Disease with Levodopa and Pramipexole Exposure

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JCOG. 2023;33(2):118-20
DOI: 10.5336/jcog.2022-93986
Article Language: EN
Copyright Ⓒ 2020 by Türkiye Klinikleri. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Parkinson's disease is a common neurodegenerative disease that rarely occurs in young people. Therefore, cases where pregnancy and Parkinson's disease occur together are very rare and pregnant patients receiving anti-Parkinsonian therapy are rarely presented as case reports in the literature. We report a case of a 36-year-old pregnant woman with a 5 year history of early onset Parkinson's disease who was exposed to levodopa/benserazide plus pramipexole treatment during the first 8 weeks, and levodopa/benserazide treatment until the 37th gestational week. The patient was followed up by the perinatology specialist at regular intervals throughout her pregnancy. No fetal anomaly was detected in the follow-ups. She gave birth to a healthy baby girl by an uncomplicated cesarean delivery. Evidence based data on the most appropriate treatment of Parkinson's disease in pregnancy have not been found in the literature. Larger studies are needed on this subject.
REFERENCES:
  1. Benbir G, Ertan S, Ozekmekci S. Successful pregnancy and delivery in a patient with Parkinson's disease under pramipexole treatment. Presse Med. 2014;43(1):83-5. [Crossref]  [PubMed] 
  2. Opara J, Małecki A, Małecka E, Socha T. Motor assessment in Parkinson's disease. Ann Agric Environ Med. 2017;24(3):411-5. [Crossref]  [PubMed] 
  3. Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999;56(1):33-9. [Crossref]  [PubMed] 
  4. Langston JW. The Parkinson's complex: parkinsonism is just the tip of the iceberg. Ann Neurol. 2006;59(4):591-6. [Crossref]  [PubMed] 
  5. Dostal M, Weber-Schoendorfer C, Sobesky J, Schaefer C. Pregnancy outcome following use of levodopa, pramipexole, ropinirole, and rotigotine for restless legs syndrome during pregnancy: a case series. Eur J Neurol. 2013;20(9):1241-6. [Crossref]  [PubMed] 
  6. Lamichhane D, Narayanan NS, Gonzalez-Alegre P. Two cases of pregnancy in Parkinson's disease. Parkinsonism Relat Disord. 2014;20(2):239-40. [Crossref]  [PubMed]  [PMC] 
  7. Olivola S, Xodo S, Olivola E, Cecchini F, Londero AP, Driul L. Parkinson's disease in pregnancy: a case report and review of the literature. Front Neurol. 2020;10:1349. [Crossref]  [PubMed]  [PMC] 
  8. Tüfekçioğlu Z, Hanağası H, Yalçın Çakmaklı G, Elibol B, Esmeli Tokuçoğlu F, Kaya ZE, et al. Use of anti-Parkinson medication during pregnancy: a case series. J Neurol. 2018;265(8):1922-9. [Crossref]  [PubMed] 
  9. Kupsch A, Oertel WH. Selegiline, pregnancy, and Parkinson's disease. Mov Disord. 1998;13(1):175-6. [Crossref]  [PubMed] 
  10. Mucchiut M, Belgrado E, Cutuli D, Antonini A, Bergonzi P. Pramipexole-treated Parkinson's disease during pregnancy. Mov Disord. 2004;19(9):1114-5. [Crossref]  [PubMed] 
  11. Cook DG, Klawans HL. Levodopa during pregnancy. Clin Neuropharmacol. 1985;8(1):93-5. [Crossref]  [PubMed] 
  12. Campos-Sousa RN, Almeida KJ, Dos Santos AR, Lopes-Costa PV, da Silva BB. Multiparity after an initial diagnosis of Parkinson's disease: a report on a rare case. Fertil Steril. 2008;90(5):2005.e1-2. [Crossref]  [PubMed] 
  13. Robottom BJ, Mullins RJ, Shulman LM. Pregnancy in Parkinson's disease: case report and discussion. Expert Rev Neurother. 2008;8(12):1799-805. [Crossref]  [PubMed] 
  14. Hagell P, Odin P, Vinge E. Pregnancy in Parkinson's disease: a review of the literature and a case report. Mov Disord. 1998;13(1):34-8. [Crossref]  [PubMed] 
  15. Seier M, Hiller A. Parkinson's disease and pregnancy: an updated review. Parkinsonism Relat Disord. 2017;40:11-7. [Crossref]  [PubMed]